Abstract
Material and methods 105 children with a diagnosis of type I allergy to fish, based on history, specific IgE (sIgE, CAP) to codfish (f3) and skin prick tests (SPT) with commercial fish extracts, are included so far. All children undergo open food challenges (OFC) with canned tuna, fresh swordfish or fresh tuna in order to evaluate whether these fishes are tolerated or not by fish allergic children. Subsequently, those children showing signs of reduced clinical reactivity are subjected to double blind placebo controlled food challenges (DBPCFC) with codfish, followed by OFC to codfish in those with a negative DBPCFC, to evaluate the natural history.
Highlights
The clinical course of fish allergy is not sufficiently studied
open food challenges (OFC) to codfish was negative in those four children and they were considered fish tolerant. Both sIgE and skin prick tests (SPT) values showed a diminishing trend in these four patients
All children undergo open food challenges (OFC) with canned tuna, fresh swordfish or fresh tuna in order to evaluate whether these fishes are tolerated or not by fish allergic children
Summary
The clinical course of fish allergy is not sufficiently studied. Persistence seems to be the dominant pattern; a number of cases may overcome this allergy with time. Due to the high structural homology of parvalbumins from different fish species, crossreactivity among fishes is common. 8 children underwent a DBPCFC to codfish and 4 were negative. OFC to codfish was negative in those four children and they were considered fish tolerant. Both sIgE and SPT values showed a diminishing trend in these four patients. The mean time between first reaction and the achievement of tolerance for these four children was 9.25 years
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