Abstract
The abortifacient effect of a single extraovular dose of 10mg PG F2α has been successfully demonstrated without additional therapy in first trimester pregnant patients. The immediate response to PG F2α was manifest as uterine pain which tapered off after about 2 hours. Slight uterine bleeding and decreased levels of plasma estradiol-17β and progesterone measured at 2 hours suggested an initial insult of PG F2α on the feto-placental unit. Subsequent reappearance of uterine activity and progressive cervical dilatation signaled effective therapy. Six patients out of 10 aborted completely in an average of 8.0 hours. The other 4 aborted their fetuses in 15.8 hours on the average but retained their placentae. Plasma steroid levels in the former group were decreased still further at the time of diagnostic curettage (22 hours); however, steroid levels remained unchanged in the latter group during the interval between 2 and 22 hours. These results suggest the possibility that, following the successful provocation of feto-placental insult by PG F2α, supplemental treatment with oxytocics might reduce instillation abortion time and increase the incidence of complete abortions.
Published Version
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