First catalytic synthesis of 7-ferrocenyl-2,4-dioxopyrido [2,3-d]pyrimidines derivatives in water

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The reaction of 6-amino-1,3-dimethyluracil with substituted ferrocenyl-ketoalkynes using nickel cyanide as homogeneous catalyst precursor in aqueous alkaline medium, affords 5-substituted-7-ferrocenyl-dioxopyrido[2,3-d]pyrimidines derivatives, in moderate yields under mild conditions.