Finite element analysis of the influence of porosity and pore geometry on mechanical properties of orthopaedic scaffolds

Abstract

PurposeScaffolds play a key role in regenerative medicine in the repair of injuries, defects and cancerous changes in long bones. For this reason, scaffolds should meet certain mechanobiological requirements, such as adequate porosity and pore geometry to ensure appropriate osteointegration as well as load transfer. Taking into account the most frequently used cell units, this study attempted to evaluate the porous structures of orthopaedic scaffolds in terms of their strength parameters. Materials and methodsFour pore geometries were selected for analyses: sphere, octagonal prism, cube and triangular prism, all with porosities of 10% up to 60%. Three different material properties were considered: Ti6Al4V alloy, CoCr alloy, 316 L steel. Strength compression simulations were carried out on 144 models, 72 structures of cell units with dimensions of 4 × 4 × 4 mm and 72 structures of scaffolds with a diameter of 16 mm and a height of 15 mm. Effective Young's modulus, as well as 0.2%, offset effective yield strength was estimated. ResultsResearch has shown that scaffolds with bone-like strength properties should be made of Ti6Al4V alloy. The value of 40% turned out to be of the best porosity. The remaining porosities showed much lower or much higher strength parameters and were significantly different from the properties of the bones. ConclusionsThe obtained data allow to indicate the most functional porous structure with Young's modulus similar to that possesses by core bone, while maintaining mechanical strength, allowing for its appropriate use in orthopaedic regenerative medicine.