Abstract
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Highlights
Selection and Peer-review under the responsibility of the PhysBioSymp17 Conference Committee.In the past decade, a variety of vivid applications of quantum dots (QDs) as in vitro and in vivo bioimaging probes has been demonstrated [1, 2]
Our preliminary experiments have shown that it is possible to considerably reduce, down to 40 times, the amount of amount of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) surfactant in the silica coating procedure of PbS QDs reported in the original procedure [4] and, as a result, to obtain stable solutions of SiO2-coated QDs
We have varied the quantities of other components of the reaction, namely tetraethyl orthosilicate (TEOS) and NH4OH, to achieve the best optical performance of silica-coated PbS QDs
Summary
Selection and Peer-review under the responsibility of the PhysBioSymp Conference Committee. A variety of vivid applications of quantum dots (QDs) as in vitro and in vivo bioimaging probes has been demonstrated [1, 2]. Since the human body has socalled “transparency windows” in the near infrared (NIR) region of optical spectrum, PbS QDs fluorescing in the NIR-region attracted a lot of attention as promising in vivo labels. The intrinsic toxicity of lead and photoluminescence (PL) instability of PbS QDs prevent their direct utility in biological experiments. One of the approaches used to render QDs biocompatible is coating of a QD with silica shell [3]. The PL quantum yield (QY) of QDs after the silanization procedure can be significantly reduced
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