Abstract
It is well known that CRF retards body growth and skeletal maturation. However, neither the relationship between growth retardation and attainment of adult height has been ascertained nor it is known at what age children with CRF cease to grow. The present study is based upon evaluation of 34 children followed 3-9 yrs after onset on CRF up to the time of epiphyseal union of the hand and wrist bones and minimal (< 1 cm/yr) or no growth since at least 1 year. 23 pts had congenital (A) and 11 acquired(B) nephropathies. Final height was attained at the average age of 18.3 yrs in males and 16.9 yrs in females. Mean final height was well below the 50th centile in both groups with no statistical difference between males and females. 7 pts(30%) in group A but only 1 in group B reached a final height < 3rd centile. There was no difference among the two groups regarding medical treatment, dietary intake and duration of dialysis, but age at first symptoms and age at onset of CRF differed significantly. It is suggested that primary renal disease and duration of CRF are major factors causing reduction of adult height in children with CRF.
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