Abstract
The skin is the most extensive and outermost organ in the body and can be greatly exploited both from the point of view of alternative routes of systemic drug delivery and treatment of dermatological diseases. Because of its main function as a barrier against harmful external agents, it also becomes a barrier to drug administration, but there are strategies to reduce this limitation of this promising route of administration. The development of polymer-based film-forming formulations is extensively studied for this purpose, since the formation of a film on the skin increases the contact time of the drug, for this being characterized as a controlled release reservoir system. There are a multitude of possible polymers to compose these formulations and their choice must be made according to the purpose of each application. This work, therefore, aims to study the state of the art of film forming systems for topical application of pharmaceutical formulations.
Highlights
Because of its main function as a barrier against harmful external agents, it becomes a barrier to drug administration, but there are strategies to reduce this limitation of this promising route of administration
Pharmaceutical research faces the major challenge of developing new technologies to give formulations different characteristics that overcome the therapeutic limitations of traditional dosage forms, including adjustable release profiles, flexibility of use, ability to carry more than one active ingredient, improve patient availability and compliance [1]
In order to evaluate how these formulations are prepared in the pharmaceutical field, some studies have been selected focusing on the development of different film forming systems for the most diverse applications in topical formulations, which are proof that these systems go far beyond traditional polymeric solution, making it necessary to perform the most varied characterization tests depending on the objective of each study
Summary
Pharmaceutical research faces the major challenge of developing new technologies to give formulations different characteristics that overcome the therapeutic limitations of traditional dosage forms, including adjustable release profiles, flexibility of use, ability to carry more than one active ingredient, improve patient availability and compliance [1]. Conventional topical dosage forms, such as cream, gels and ointments, are called semisolids. These usually have an unattractive sensory appearance and do not guarantee prolonged skin contact with the drug, requiring repeated applications throughout the day and may cause less patient adherence to treatment. The development of formulations that overcome this technological barrier may be crucial for improving the treatment of dermatological diseases [4] [5] In this context, polymeric film-forming systems are being explored both in the treatment of dermatological diseases and in cosmetic products as potential formulations to reduce the inconveniences of topical application [4]. The main objective of review will be to elucidate the anatomophysiological characteristics of the skin and to conduct a survey of the state of the art of film forming systems in the topical release of pharmaceutical agents
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