Abstract
Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the formulation forms a solid film. Various film-forming formulations were tested for their water and abrasion resistance and compared with conventional semi-solid formulations. Penetration and permeation studies of the formulations indicate a potential utility as transdermal therapeutic systems. They can be used as an alternative to patch systems to administer a variety of drugs in a topical way and may provide sustained release characteristics.
Highlights
The epidermis can be divided into four layers, with the stratum corneum being on top, followed by the stratum granulosum, stratum spinosum, and stratum basale [4]
According to previous research findings, film-forming systems have proven to be suitable for use as a delivery form due to their high substantivity and cosmetic attractiveness
The formulations serve as a depot, which enables a sustained release
Summary
The skin regulates physiological parameters of the body by providing a barrier against water evaporation and temperature loss [2]. Skin diseases such as infections triggered by bacteria or viruses, as well as the immunologically caused chronic skin diseases psoriasis, atopic dermatitis, urticaria, or ichthyosis damage the skin barrier. Physiological functions can no longer be maintained, increasing the risk of further infection. Symptoms such as pain, soreness, and wetness affect the patients’ quality of life [3]
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