Figures of merit for comparing reconstruction algorithms with a volume-imaging PET scanner

Abstract

For volume-imaging PET scanners, no septa are used to maximize the sensitivity by collecting events oblique to the scanner axis. The authors answer two questions: (i) how does the performance of an image reconstruction algorithm for a volume-imaging PET scanner depend on its general dimensions? and (ii) at what point is a three-dimensional (3D) reconstruction algorithm needed for a volume-imaging scanner, as the axial extent is increased? A 3D reconstruction algorithm will accurately incorporate the oblique events in a reconstruction of the original source distribution. From simulations of an existing volume PET scanner with a maximum axial acceptance angle (+or- alpha ) of alpha =9 degrees , however, the authors show that the single-slice rebinning algorithm is a good compromise between sensitivity, speed, and accuracy when compared to standard two-dimensional reconstruction ( alpha =1 degrees ), and a 3D reconstruction with alpha =9 degrees . The authors also show with simulations that a new scanner with alpha =27 degrees requires 3D reconstruction in order to achieve maximum sensitivity without unacceptable losses in accuracy. Measurements of scanner performance are based on a series of figures of merit that characterize image quality and quantitative accuracy measured from a set of simulated test phantoms.