Figure S1 from Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced <sup>2</sup>H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength

Abstract

<p>Sensitivity of in vivo deuterium MRI and kinetics of 2H enrichments in C26 xenograft-bearing BALB/c-nu mice allowed to drink D2O freely (A) Representative coronal deuterium MRI images of the distribution of 2H in the body of C26 colorectal carcinoma xenograft-bearing mice during 10 days of D2O administration. Images were collected on days 1, 3, 7, and 10 of the first exposure to D2O. (B) Representative T1-weighted MRI images of mouse body parts. (C) Full-body MRI images after placing the MRI images of three body parts together show the distribution of 2H and 1H signals collected throughout the body. (D) Quantification of 2H MRI signals of body tissues. Analysis was performed using Image J software. The data show the means ± SD (n=5).</p>