Abstract
Fight fat with DGAT
Highlights
The triglyceride synthesis pathway is active in virtually every cell type
DGAT1 overexpression leads to increased cellular TG storage in white adipose tissue, skeletal muscle, and liver in a tissue-specific manner and thereby limits the amounts of intracellular DAG and free fatty acids
The absence of DGAT1 did not lead to elevated levels of DAG or acyl-CoA in muscle, liver, and adipose tissue upon high-fat diet feeding [8]
Summary
The triglyceride synthesis pathway is active in virtually every cell type. Conversion of fatty acids into triglycerides (TGs) serves two main purposes. Loss- and gain-of-function studies have revealed that the role of DGAT1 is diverse and, in addition to regulating cellular TG storage levels, affects the development of obesity, insulin resistance, and fatty acid-induced inflammation [5, 6]. DGAT1 overexpression leads to increased cellular TG storage in white adipose tissue, skeletal muscle, and liver in a tissue-specific manner and thereby limits the amounts of intracellular DAG and free fatty acids.
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