Abstract
Hemodiafiltration (HDF) with elevated substitution fluid offers an optimal way of removing uremic substances. The beginnings of HDF and on-line HDF, learning curve, differences in the removal of uremic toxins, difficulties in the development, automated manual Q(i) as a practical way of prescribing, distinct experiences with on-line HDF and prospective, randomized ongoing on-line HDF studies are detailed as a personal vision for 15 years' handling with on-line HDF.
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