Abstract
A brief review of current data on the generality of the epidemiology and molecular pathogenesis of breast cancer and benign breast diseases is presented. Currently, a type of mastopathy, fibrosclerosis/sclerosing adenosis, accompanied by the formation of microcalcifications, is considered as a benign pathological condition with a high risk of malignancy, and also as a pre-start condition of a possible transition of mastopathy to cancer. In the review is discussed the fundamental biological process of the epithelial-mesenchymal transition (EMT) as a molecular pathogenetic basis of this phenomenon. Identification of the above mentioned pathological changes using mammography and refined diagnostics using a vacuum aspiration biopsy allow timely treatment of fibrosclerosis and sclerosing adenosis with Indinol® Forto, a drug of pathogenetic action based on indole-3-carbinol, due to its multiple anticancer and oncoprophylactic activity, including ability to reverse at the epigenetic level the EMT process abnormally proceeding in these benign breast diseases.
Highlights
Исследования и практика в медицине 2019, т.6, No2, с. 75-85 Е.Л.Муйжнек и др. / Фибросклероз и склерозирующий аденоз с микрокальцинатами в молочной железе
Microcalcifications in breast cancer: an active phenomenon mediated by epithelial cells with mesenchymal characteristics
Summary
Исследования и практика в медицине 2019, т.6, No2, с. 75-85 Е.Л.Муйжнек и др. / Фибросклероз и склерозирующий аденоз с микрокальцинатами в молочной железе. При этом выявляется четкая корреляция между повышенным риском РМЖ и выраженностью гиперплазии и атипических клеточных изменений в тканях молочной железы [17]. Что при протоковой карциноме in situ молочной железы в миоэпителиальных клетках отмечается пониженная экспрессия генов, характерных для нормального клеточного функционирования, и, напротив, повышенная экспрессия генов, стимулирующих клеточную пролиферацию, миграцию, инвазию и ангиогенез [33,34,35].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
