Abstract

Fibromyalgia in Women with Acne Vulgaris

Highlights

  • Skin is the human body’s main interface with the external environment; the skin is considered as the body’s major public relations tool [1]

  • Fibromyalgia syndrome (FMS) is a chronic diffuse widespread pain condition associated with other symptoms including morning stiffness, anxiety, fatigue, sleep disturbance, and cognitive problems [7,8]

  • The prevalence rate of FMS among women with acne vulgaris was found to be 30.0% which is higher when compared to a study done by Yazmalar et al [20] who found FMS was affected 16% of women in his study group, and another study done by Thune [17] who found FMS was affected 13% of women with psoriasis which is another distressing skin disease, and it seems to be low when compared to a study done by Torresani et al [21] who found the prevalence rate of FMS was 53.9% in women with chronic urticaria

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Summary

Introduction

Skin is the human body’s main interface with the external environment; the skin is considered as the body’s major public relations tool [1]. The pathogenesis of acne vulgaris is multifactorial, in addition to the genetic predisposition, bacterial infections, hormonal disorders, sun exposure, smoking, and diet; stress play a crucial role in the pathogenesis of acne vulgaris [6]. Stress can modulate different adhesion molecules [10], there is a significant reduction in L-selectin and b2-integrin expression on the surface of polymorphonuclear leukocytes in patients with FMS [10]. These adhesion molecules play a crucial role in the destruction of infectious agents and removing toxic substances from the body. Widespread pain and fibromyalgia syndrome (FMS) are observed in many patients with autoimmune and inflammatory disorders

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