Fibrinolytic response to physical exercise in males

Abstract

The authors investigated changes in coagulation and fibrinolysis which occurred after moderate physical exercise in young normal males, aged normal males and male patients with complications of atherosclerosis. It was found that all three groups developed a hypercoagulable state of similar intensity after exercise, while the fibrinolytic response differed in each; the increase was in the order of 140% in young normal males, 40% in aged normal males, and 20% in the atherosclerotic patients. It therefore seems that the homoeostatic equilibrium which in young normal individuals exists between the response of coagulation and that of fibrinolysis to exercise, tends to disappear with increasing age and with the occurrence of atherosclerotic complications.