Abstract
Objective. This research aims at estimating the changes of fibrinolytic activity of the blood plasma in gastroduodenopathies induced by non-steroidal anti-inflammatory drugs in patients with osteoarthrosis regarding the pathogenic Helicobacter pylori strains presence.Material and methods. The study involved 68 patients suffering from osteoarthrosis with concomitant Helicobacter pylori-associated gastro-duodenopathies induced by non-steroidal anti-inflammatory drugs. The patients were divided into groups depending on the presence of vacA and cagA Helicobacter pylori strains. Helicobacter pylori strains were detected in the stool, blood and biopsy samples using the technique of polymerase chain reaction. All the patients were investigated by means of general, clinical, laboratory and instrumental methods of examination. The computations were done using «Biostatistics» and «Statistica® 6.0» (StatSoftІnc., USA) programs. Results. The increase in the intensity of the fibrinolytic activity of the blood plasma was observed in all investigated patients. However, the patients with concomitant Helicobacter pylori pathogenic and ulcerogenic strain cagA+/vacA+ experienced an increase in total fibrinolytic activity by 13,14% and 36,4% respectively compared to the patients with cagA+/vacA- Helicobacter pylori strains and by 26,92% and 60,0% compared to the patients with cagA-/vacA+ Helicobacter pylori strains. Nonenzymatic fibrinolytic activity in patients with cagA+/vacA+ Helicobacter pylori strains tended to increase in comparison with cagA+/vacA- strains and cagA-/vacA+ Helicobacter pylori strains. Conclusion. A substantial increase in the fibrinolytic activity of the blood plasma in the examined patients with Helicobacter pylori vacA+/cagA+ compared to the patients with Helicobacter pylori vacA+/cagAand Helicobacter pylori vacA-/cagA+ has been reliably established.
Highlights
Мета дослідження — оцінити зміни фібринолітичної активності плазми крові при гастродуоденопатіях, індукованих нестероїдними протизапальними препаратами, у хворих на остеоартроз залежно від наявності патогенних штамів Helicobacter pylori
This research aims at estimating the changes of fibrinolytic activity of the blood plasma in gastroduodenopathies induced by non-steroidal anti-inflammatory drugs in patients with osteoarthrosis regarding the pathogenic Helicobacter pylori strains presence
The study involved 68 patients suffering from osteoarthrosis with concomitant Helicobacter pylori-associated gastrohttps://www.bsmu.edu.ua duodenopathies induced by non-steroidal anti-inflammatory drugs.The patients were divided into groups depending on the presence of vacA and cagA Helicobacter pylori strains
Summary
Мета дослідження — оцінити зміни фібринолітичної активності плазми крові при гастродуоденопатіях, індукованих нестероїдними протизапальними препаратами, у хворих на остеоартроз залежно від наявності патогенних штамів Helicobacter pylori. Під час дослідження обстежено 68 хворих на остеоартроз із супутніми Helicobacter pylori — асоційованими гастродуоденопатіями, індукованими нестероїдними протизапальними препаратами. Розподіл пацієнтів на групи здійснювався залежно від наявності штамів Helicobacter pylori vac A та cag A.
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