Abstract
A unique characteristic of normal human placenta is the presence of “fibrinoid”, a fibrin-rich extracellular deposit in numerous sites (1–5). Fibrinoid is absent from comparable sites of other normal tissues, displays the typical electron microscopic periodicity of fibrin polymers (1), and in addition to fibrin it contains intact fibrinogen (6). The origin of these fibrin/fibrinogen (FA) deposits is uncertain. The intracytoplasmic presence of FA in interstitial (e.g. a commonly known type is intermediate) trophoblasts not residing near villous or other vascular structures (3), however, is inconsistent with a maternal origin of FA in that these cells migrate to the villous surface and differentiate into syncytial trophoblasts (1). The present studies describe the copresence of fibrinogen mRNA and FA in trophoblasts in situ.
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