Maintaining the integrity of trophoblast during growth of the placenta. Focus on “Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta”

Abstract

maternal-fetal exchange of nutrients and respiratory gases occurs across the brush border of the trophoblast lining the intervillous space of the placenta. The trophoblast is syncytial in nature and has a high rate of turnover. Therefore syncytiotrophoblast is continually replenished from an