Fibrinogen derivatives in particle aggregation by peritoneal contents

Abstract

Summary Supernatants of peritoneal washings of normal mice and solutions of human or murine fibrinogen aggregated carbon in indian ink, colloidal saccharated iron oxide and suspensions of polystyrene latex, but did not clump thorotrast or colloidal gold. In peritoneal washings allowed to stand, the ability to aggregate tended to appear and then disappear; solutions of purified fibrinogen became active after dilution and standing. Fibrinolytic digestion of carbon clumped by mouse peritoneal supernatants or by fibrinogen, released soluble products possessing the serological specificity of fibrinogen. Early fibrinogen degradation products are thought to be the agents in peritoneal washings causing aggregation of the particles.