Abstract
The association of the fibroblast growth factor receptor 2 gene (FGFR2) polymorphism rs2981582 with breast cancer has been extensively studied, whereas the role of this polymorphism in non-functioning pituitary adenoma (NFPA) has not been elucidated. We thus investigated a potential association of rs2981582 with NFPA. A total of 79 patients and 142 healthy control participants were enrolled in our study. DNA of the participants was extracted from peripheral blood samples and genotyped by using the MassARRAY method. We found that the AA genotype was associated with a higher risk of developing NFPA (OR = 1.743, 95%CI: 1.151–2.64, P=0.008). After adjusting for risk factors, significant difference was still observed between the two groups (OR = 1.862, 95%CI: 1.172–2.957, P=0.008). Moreover, under the assumptions of the recessive model (OR = 3.051, 95%CI: 1.403–6.635, P=0.005) and the additive model (AG: OR = 0.329, 95%CI: 0.144–0.755, P=0.009; AA: OR = 0.326, 95%CI: 0.141–0.757, P=0.009), rs2981582 was associated with an increased risk of NFPA. Our results proved that FGFR2 rs2981582 AA genotype was associated with a higher risk of NFPA. The recessive model and additive model also showed increased the risk of NFPA.
Highlights
Non-functioning pituitary adenomas (NFPAs) are benign pituitary neoplasms that arise from adenohypophyseal cells and are not associated with any clinical syndrome related to hormone overproduction from the tumor [1,2]
We found that the AA allele significantly correlated with NFPA morbidity (OR = 1.743, 95%CI: 1.151–2.64, P=0.008) even after adjusting for gender, age, bodyweight, smoking, or drinking habits (OR = 1.862, 95%CI: 1.172–2.957, P=0.008) (Table 4)
Our results have demonstrated that Fibroblast growth factor receptor 2 (FGFR2) rs2981582 AA genotype or the recessive model was associated with a higher risk of NFPA
Summary
Non-functioning pituitary adenomas (NFPAs) are benign pituitary neoplasms that arise from adenohypophyseal cells and are not associated with any clinical syndrome related to hormone overproduction from the tumor [1,2]. NFPAs constitute 15–37% of all pituitary adenomas and have a prevalence of 70–220 per million in the population [3] It is the most common type of adult pituitary macroadenoma, and its most frequent clinical symptoms are headache, visual defects, and hypopituitarism [4,5,6]. Glebauskiene et al observed that the FGFR2 rs2981582 G/G genotype was observed less frequently in the non-invasive PA subgroup than in healthy controls, whereas the G/A genotype was more frequently c 2018 The Author(s). Given that the relationship between rs2981582 variants and NFPA is still unknown, we sought to assess the impact of FGFR2 rs2981582 on sporadic NFPA and determine a possible association of rs2981582 variants with NFPA risk in Chinese population in a case–control study
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