Abstract
Fibroblast growth factor 10 (FGF10) plays an important role in mouse lung development, injury, and repair. It is considered the main morphogen driving lung branching morphogenesis in rodents. While many studies have found FGF10 SNPs associated with COPD and branch variants in COPD smokers, there is no evidence of a causative role for FGF10 or these SNPs in human lung development and pediatric lung diseases. We and others have shown divergent roles for FGF10 in mouse lung development and early human lung development. Herein, we only review the existing literature on FGF signaling in human lung development and pediatric human lung diseases, comparing what is known in mouse lung to that in human lung.
Highlights
The mammalian lung is derived from invagination of the foregut endoderm that forms the primitive lung buds
In the present concise review, we mainly focus on FGF signaling during human lung development and congenital/pediatric human lung diseases
The role of Fibroblast growth factor 10 (FGF10) signaling in human lung development and disease remains poorly understood
Summary
The mammalian lung is derived from invagination of the foregut endoderm that forms the primitive lung buds. We and others have demonstrated that during the pseudoglandular stage of human lung development, the distal epithelial cells express a double positive SOX2/SOX9 progenitor cell population that is no longer present during the canalicular stage of development, suggesting its importance to human lung branching morphogenesis (Figure 2) (Nikolic et al, 2017; Miller et al, 2018; Danopoulos et al, 2018a). This difference of progenitor cell populations is accompanied by a change in smooth muscle cell expression. Fgf is highly expressed in the mesenchyme adjacent to the epithelial tips and in the smooth muscle cells surrounding the airways; whereas in humans FGF10+ cells are found dispersed throughout the mesenchyme with little expression in the smooth muscle cells
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
