Abstract
Commentary: A Breath of Fresh Air on the Mesenchyme: Impact of Impaired Mesenchymal Development on the Pathogenesis of Bronchopulmonary Dysplasia.
Highlights
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity that is only beginning to be understood at the molecular level
Secondary septa formation is a critical step in alveologenesis, with alveolar simplification in BPD thought to result from disordered septation
Summary
A breath of fresh air on the mesenchyme: impact of impaired mesenchymal development on the pathogenesis of bronchopulmonary dysplasia by Chao C-M, El Agha E, Tiozzo C, Minoo P, Bellusci S. Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity that is only beginning to be understood at the molecular level. The review by Chao et al [1] elegantly takes us through mouse and human lung development to identify possible mediators of the abnormal mesenchymal response characteristic of the disease.
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