Abstract
The analysis of constituents of the amniotic fluid with the objective of determining fetal maturity has been of increasing interest. Reported herein are the results of our attempts to establish normal values for amniotic fluid creatinine, bilirubin, and cytologic features at various stages of gestation, and then, using these values, to judge the accuracy with which they predicted approximate delivery dates and fetal weights in a series of pregnancies of unknown duration. In general, we have found that amniotic fluid cytologic features and creatinine levels allow us to predict with good accuracy the presence of an infant of at least 2,500 grams and/or a gestational age of 35 weeks. We have been even more struck, however, with the possible insight into intrauterine physiology that may come with greater understanding of the phenomena reported here.
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