Abstract

Malnutrition in fetal life and during suckling have in some animal studies resulted in adaptive changes related to the fat and glucose metabolism, which in the long term might predispose the offspring for metabolic disorders such as obesity later in life. The objective was to study the effect of fetal life malnutrition in male mink on the gene expression of leptin and adiponectin in different adipose tissue sites. Thirty-two male mink, strict carnivore species, exposed to low (FL) or adequate (FA) protein provision the last 16.3 ± 1.8 days of fetal life and randomly assigned to a low (LP) or adequate (AP) protein diet from 7 to 9.5 weeks of age were used. Adipose tissues (subcutaneous, perirenal and mesenteric) were analyzed using qPCR. Fetal life or post-weaning protein provision did not affect the relative abundances of leptin and adiponectin mRNAs in adipose tissue at 9.5 weeks of age. Relative abundances of leptin and adiponectin mRNAs were different between adipose tissue sites and were significantly higher in subcutaneous than in perirenal and mesenteric tissues. Fetal life protein malnutrition in male mink, did not result in adaptive changes in the gene expression of leptin and adiponectin mRNAs in adipose tissue at 9.5 weeks of age as found in rodents. However, both leptin and adiponectin mRNAs were significantly differently expressed between tissue sites.

Highlights

  • An imbalance between fetal demand and maternal nutrient supply may lead to metabolic adaptive changes in the fetus which may benefit the fetus in the short term, by reducing fetal growth and thereby increasing nutrient availability, but might in the long term predispose the offspring to a range of diseases postnatally, such as obesity, if the changes persist

  • Fetal life malnutrition is not reflected in the relative abundance of adiponectin and leptin mRNA in adipose tissue in male mink kits at 9.5 weeks of age Connie Frank Matthiesen1*, Anne-Helene Tauson1,2

  • In conclusion, fetal life protein malnutrition was not reflected in adipose tissue relative abundances of leptin and adiponectin mRNA in 9.5 weeks old kits

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Summary

Open Access

Fetal life malnutrition is not reflected in the relative abundance of adiponectin and leptin mRNA in adipose tissue in male mink kits at 9.5 weeks of age Connie Frank Matthiesen1*, Anne-Helene Tauson. From Animal Obesity - causes, consequences and comparative aspects Uppsala, Sweden. From Animal Obesity - causes, consequences and comparative aspects Uppsala, Sweden. 14-16 June 2015

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