Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the deposition of extracellular amyloid-beta peptide (Aβ) and intracellular neurofibrillar tangles, associated with loss of neurons in the brain and consequent learning and memory deficits. Aβ is the major component of the senile plaques and is believed to play a central role in the development and progress of AD both in oligomer and fibril forms. Inhibition of the formation of Aβ fibrils as well as the destabilization of preformed Aβ in the Central Nervous System (CNS) would be an attractive therapeutic target for the treatment of AD. Moreover, a large number of studies indicate that oxidative stress and mitochondrial dysfunction may play an important role in AD and their suppression or reduction via antioxidant use could be a promising preventive or therapeutic intervention for AD patients. Many antioxidant compounds have been demonstrated to protect the brain from Aβ neurotoxicity. Ferulic acid (FA) is an antioxidant naturally present in plant cell walls with anti-inflammatory activities and it is able to act as a free radical scavenger. Here we present the role of FA as inhibitor or disaggregating agent of amyloid structures as well as its effects on biological models.
Highlights
IntroductionFerulic acid (4-hydroxy-3-methoxycinnamic acid, FA) is a widely distributed constituent of plants
Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) is a widely distributed constituent of plants.It was first isolated from Ferula foetida, the plant from which its name has been derived, in 1866
Molecules, which represent the major phytochemical of fruit, component Natural of these aromatic non-covalent interactions accounts for mutual orientation patternscomponents in aromatic-aromatic vegetables, beverages, and grains, have recently received increasing attention for their anti-aging effects and benefits for human health mainly due to significant free radical scavenging properties and antioxidant activity
Summary
Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) is a widely distributed constituent of plants. Arabinoxylans, and hemicelluloses, FA becomes part of the lignin polymer [4], conferring rigidity to cell walls It can be found free, in dimerized form, or esterified with proteins and polysaccharides in a wide variety of natural products [5]. From a chemical point of view, FA belongs to the broad class of phenols, in particular to the hydroxycinnamic acids They can exist both in cis and trans forms, the latter being the most stable and diffused in nature [26]. They can exist both in cis and trans forms, the latter being the most stable and Nutrients. In the current review we will focus on the effects of FA, illustrating the role of FA as inhibitor or disaggregating agent of amyloid structures as well as its effects on biological models
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