Abstract
Lynch syndrome (LS) is an autosomal dominant hereditary tumor syndrome characterized by tumors in the uterus and ovaries of female patients. Atypical endometrial hyperplasia (AH) or endometrial carcinoma (EC) in LS patients is caused by germline mutations. Few studies have analyzed the role of estrogen or the role of fertility-sparing therapies for these patients. Here we reported a LS patient who had AH and attempted to preserve her fertility under close monitoring and after multidisciplinary consultations. The lesion was completely reversed after 3 months of treatment with levonorgestrel-releasing intrauterine system (LNG-IUS), and no recurrence was noted during the 9-month follow-up. The possibility of LS should be considered in AH patients with a family history of relevant cancers. Meanwhile, for LS patients with complicated AH and a strong desire to retain infertility, fertility-sparing treatment may be attempted to reverse endometrial lesions under close monitoring and after adequate evaluation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.