Abstract
Aim The aim of this official guideline published by the German Society of Gynecology and Obstetrics (DGGG) and coordinated with the German Society of Urology (DGU) and the German Society of Reproductive Medicine (DGRM) is to provide consensus-based recommendations, obtained by evaluating the relevant literature, on counseling and fertility preservation for prepubertal girls and boys as well as patients of reproductive age. Statements and recommendations for girls and women are presented below. Statements or recommendations for boys and men are not the focus of this guideline. Methods This S2k guideline was developed at the suggestion of the guideline commission of the DGGG, DGU and DGRM and represents the structured consensus of representative members from various professional associations (n = 40). Recommendations The guideline provides recommendations on counseling and fertility preservation for women and girls which take account of the patientʼs personal circumstances, the planned oncologic therapy and the individual risk profile as well as the preferred approach for selected tumor entities.
Highlights
Introduction to Fertility Protection for PersonsDiagnosed with Oncologic Disease1.2 Importance and problems of fertility protection for persons diagnosed with cancerOncologic therapies often lead to partial or complete impairment of gonadal function in both men and women along with the potential loss of germ cells
Whether women develop ovarian insufficiency depends on the radiation dose, the age when the patient was exposed to radiation and the volume of irradiated ovarian tissue
Slow freezing is currently recommended for the cryopreservation of ovarian tissue because of the higher efficacy of this method in routine clinical practice [12 – 14]
Summary
Information on the guidelines program of the DGGG, OEGGG and SGGG is provided at the end of the article. V.] (DGU) German Society of Gynecology and Obstetrics [Deutsche Gesellschaft für Gynäkologie und Geburtshilfe e. V.] (AGO) Professional Association of Gynecologists (BVF) German Society for Gynecologic Endocrinology and Reproductive Medicine [Deutsche Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin e. V.] (DGS) Internal Oncology Working Group [Arbeitsgemeinschaft Internistische Onkologie] (AIO); German Society for Hematology and Medical Oncology [Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e. V.] (DGHO) AG PRIo of the DKG [German Cancer Society] Federal Association of Reproductive Medicine Centers in Germany (BRZ) FertiPROTEKT Network Human Reproductive Biology Working Group [Arbeitsgemeinschaft Reproduktionsbiologie des Menschen e. V.] (BKiD) Professional Association of Practice-based Gynecologic Oncologists in Germany (BNGO) German Society for Endocrinology (DGE); Austrian Society of Gynecology and Obstetrics [Österreichische Gesellschaft für Gynäkologie und Geburtshilfe e.
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