Ferroptosis-modulating natural products for targeting inflammation-related diseases: Challenges and opportunities in manipulating redox signaling.

Abstract

A number of disorders are associated with ferroptosis, a non-apoptotic programmed cell death brought on by lipid peroxidation buildup. Inflammation is the body's defensive reaction to stimuli, and it is also a result of inflammatory chemicals that harm the body. Treating inflammatory illnesses by focusing on ferroptosis's signaling routes and mechanisms has emerged as a new area of intense study interest. In cellular and animal models of inflammatory illnesses, it has been found that ferroptosis markers are triggered and lipid peroxidation is elevated. Natural products (NPs) are becoming more and more significant in this regard because of their ability to target ferroptosis pathways, particularly the Nrf2 signaling pathway, and so suppress inflammation and the release of pro-inflammatory cytokines. An overview of ferroptosis is given in this article, with particular attention to the signaling pathways and action mechanisms that connect it to inflammation. It also looks at how NPs might be used as a treatment to stop inflammatory illnesses and ferroptosis. NPs have unique advantages, such as multi-component, multi-bio-targets, and low side effects. More research may enable NPs to be used in clinical settings early on to develop innovative treatment strategies.