Abstract
We have designed and synthesized two α-helicomimetic foldamers composed of six urea residues with terminal ferrocene and cysteamine moieties. The direction of the net dipole moment in these two com...
Highlights
Self-assembled monolayers (SAMs) of thiol derivatives are broadly employed as model systems for fundamental studies[1] as well as for applications in numerous fields such as sensor design,[2−4] molecular electronics,[5−7] biochemical assays,[8] and lubrication.[9]
The conformation of the obtained foldamers was investigated by electronic circular dichroism (CD) (ECD) and NMR spectroscopy (Figure 2)
Because the oligoureas studied in this work show a significant difference in potential-induced molecular dynamics, we have explored how it affects the rates of electron transfer through monolayers composed of HS-6u-Fc and Fc6u-SH
Summary
Self-assembled monolayers (SAMs) of thiol derivatives are broadly employed as model systems for fundamental studies[1] as well as for applications in numerous fields such as sensor design,[2−4] molecular electronics,[5−7] biochemical assays,[8] and lubrication.[9] They are often considered as a unique platform for designing functional and controllable surface structures with tunable chemical properties These include redox-active SAMs, which were found to be advantageous as mediators in electrochemical sensing related to biomedical applications[10] and proved to be useful in investigations of the basic aspects of interfacial charge transfer.[11,12] Among numerous compounds, peptides were frequently used for such studies because of the structural diversity of possible structures.[13] This enables fine tuning of their electron transfer properties by controlling the secondary structure of the peptide.[14] peptide-based architectures have certain drawbacks, which are related to poorly defined secondary structures in short amino acid sequences.
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