Abstract
A new amphiphilic polynorbornene-based copolymer P1 was designed and synthesized successfully by ring-opening metathesis polymerization (ROMP) of polyethylene glycol (PEG) containing monomer NB-PEG and ferreocene-anchored monomer NB-Fc. The copolymer P1 can bind with anionic uranine dye (UD) through multiple interactions to form no fluorescent P1/UD nano-structure ensemble in aqueous solution. The P1/UD ensemble can be used as indicator displacement assay (IDA) for ATP detection with a high sensitivity and selectivity. Upon the addition of ATP, the fluorescence is significant enhanced for displacement of UD from P1/UD ensemble. The LOD value of P1/UD ensemble toward ATP is as low as 35.9 nM. The P1/UD ensemble exhibits an excellent photo-stability and biocompatibility, and has been successfully used for imaging ATP in living cells.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
