Abstract
Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12-months aged mice which were given fenugreek seed dietary supplement. We evaluated the activities of various antioxidant defense enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and also estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx, and GR activities in aged mice liver revealed a significant (p < 0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect on the activities of the hepatic antioxidant defense enzymes in the aged mice.
Highlights
Aging is a syndrome of changes that are deleterious, progressive, universal, and far irreversible.Aging changes occur to molecules, to cells, and to organs
There was a significant decrease in the levels of glutathione peroxidase (GPx) and GR1 enzyme levels in the aged mice liver which clearly shows that the fenugreek seeds dietary supplement substantially decreases the GPx and GR1 level in a dose-dependent manner
This study provides clear evidence about fenugreek supplementation modulatory action targeting the antioxidant defense systems in the livers of aging mice
Summary
Aging is a syndrome of changes that are deleterious, progressive, universal, and far irreversible. Aging changes occur to molecules, to cells, and to organs. Accumulation of toxic material in different tissues is observed. Aging is an aggregation of destruction or impairment of various cells, Nutrients 2020, 12, 2552; doi:10.3390/nu12092552 www.mdpi.com/journal/nutrients. Nutrients 2020, 12, 2552 molecules, and tissues over a lifetime, which mostly leads to malfunction and frailty. Apart from other processes, old age is considered as the biggest risk factor for several diseases conditions, including cardiovascular, neurodegenerative diseases, and cancer [1]. For explanation of ageing process, over 300 theories have been proposed [2], none out of these is uniformly accepted by gerontologists
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