Female Renal Tubule-Specific Adipose Triglyceride Lipase Knockout Mice Develop Glucose Intolerance With Advancing Age

Abstract

Classical rodent obesity models implicate renal steatosis and lipotoxicity in the pathology of type 2 diabetes (T2D), but are confounded by myriad of metabolic changes. To study effects of isolated renal steatosis, we have generated renal tubule-specific adipose triglyceride lipase knockout (RT-SAKO) mice. Initial work from our laboratory has found glucose intolerance, without insulin resistance, in young male RT-SAKO mice, but not in females. Women have an older age of onset of T2D than men, therefore, we have studied the physiology and glycemic control of older female RT-SAKO mice.