Abstract
BackgroundImmunocompromised (IC) patients have an increased risk of refractory diarrhea. Fecal microbiota transplantation (FMT) is a safe and effective therapy for infection-related diarrhea which are mainly mediated by the loss of the microbial colonization, although there is concern that IC patients may be at higher risk of infectious complications related to FMT. And reports of FMT in IC children are limited.Case presentationWe describe two cases of FMT in IC children with refractory diarrhea. One IC child had polyendocrinopathy, enteropathy, X-linked syndrome and the other child had graft-versus-host disease. Both of the children had a long course of diarrhea and no response to traditional treatment. FMT was performed on both patients via nasojejunal tubes under guidance of gastroduodenoscopy. After FMT, the patients achieved remission of symptoms and neither of them had related infectious complications. Microbiota analysis showed that FMT resulted in reconstruction of a diverse microbiota.ConclusionsUse of FMT is safe and effective in treatment of refractory diarrhea in IC children with a damaged microbiota.
Highlights
Immunocompromised (IC) patients have an increased risk of refractory diarrhea
We report here two consecutive IC children who received Fecal microbiota transplantation (FMT) at our institution
Case 1 After 1 month of antibiotics for repeated pneumonia, a 2year-old boy with a history of polyendocrinopathy, enteropathy, X-linked syndrome presented with watery diarrhea for longer than 4 months
Summary
Immunocompromised (IC) patients have an increased risk of refractory diarrhea. Fecal microbiota transplantation (FMT) is a safe and effective therapy for infection-related diarrhea which are mainly mediated by the loss of the microbial colonization, there is concern that IC patients may be at higher risk of infectious complications related to FMT. Conclusions: Use of FMT is safe and effective in treatment of refractory diarrhea in IC children with a damaged microbiota. Fecal microbiota transplantation (FMT) is increasingly being used as an effective therapy for recurrent Clostridium difficile infection (CDI) in adults when Because of ongoing diarrhea that was unresponsive to conventional treatment, the patient underwent two times of FMT via a jejunal tube under the guidance of gastroduodenoscopy.
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