Abstract
Durif et al. studied the effect of clozapine on levodopa-induced dyskinesias (LID) in 50 parkinsonian patients in a 10-week randomized placebo-controlled study. The duration of LID was reduced by 2 hours and their intensities by 50%. The mean clozapine dose was 40 mg. Three patients in the clozapine group developed hypereosinophilia, which resolved rapidly after stopping the drug. see page 381 Commentary by Robert L. Rodnitzky, MD Levodopa-induced dyskinesia (LID) is a source of motoric or social disability in a significant percentage of patients undergoing treatment for …
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