Abstract
The antigens of Yersinia ruckeri, Aeromonas salmonicida sp.salmonicida, Listonella anguillarum and Renibacterium salmoninarum were immunized to rainbow trout of different ages immersion and intraperitaneal, then waited 300 degree days, after which they were infected with homologous and heterologous strains of the studied microorganisms. Prepared antigens and their various combinations were used in the experiments. After the control infection, the level of protective immunity was compared. The level of antibacterial protection obtained by the introduction of polyvalent variants was comparable to that acquired from the introduction of monovalent antigens. A number of cross–reactions were detected - so vaccination with pure A. salmonicida antigen provided some protection against infection with L. anguillarum and Y. ruckeri. In addition, the addition of R. salmoninarum antigen in combination enhanced the protective effect against other diseases to a greater extent than from homologous infection.
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