Features of the hormonal background of women with infertility on the background of endometriosis and methods of their correction

Abstract

Endometriosis-associated infertility is characterized by a number of specific features that must be considered when choosing treatment methods. In each case, treatment should be individual, taking into account all clinical factors, as well as the impact of the disease and the effect of treatment on the quality of woman’s life. Objective – to analyze the concentration of the reproductive system hormones in women with endometriosis-associated infertility before and after sclerotherapy using pregravidary preparation with a complex vitamin medication with inositol and vitamin D3. The study included 70 women aged 21-40 years with endometriosis-associated infertility. The comparison group included 30 women with tuboperitoneal infertility factor. Determination of the concentration of the reproductive system hormones was performed in an accredited laboratory of the “Professor S. Khmil Clinic Medical Center” with the help of “Diagnostic Systems Laboratories, Inc.” test system (USA) using the analyzer “StatFax”. The medicament FT 500 plus was prescribed in a dosage of 1 sachet – once a day from the 2nd or 3rd day of the cycle during 2 menstrual cycles (cycle in which sclerotherapy was performed and subsequent cycle) for 1 group. Vitamin D3 was prescribed in prophylactic doses of 2.000 IU to women who were not diagnosed with a deficiency of this vitamin and in medium therapeutic doses for hypovitaminosis during 2 menstrual cycles. The sclerotherapy procedure was performed in a sterile operating room on the 6th – 8th day of the menstrual cycle by transvaginal puncture of the cyst and aspiration of its contents under the control of transvaginal ultrasound, introduction into the cyst capsule 95 % ethanol solution. Women with endometriosis-associated infertility, who were prescribed pregravidary preparation with a complex vitamin medication with inositol and vitamin D3 and sclerotherapy had probably lower levels of AMH (by 12.90 %), progesterone (by 9.84 %) and probably higher levels of FSH (by 14.47 %), LH (by 21.14 %) estradiol (by 35.55 %) relative to the comparison group. At the same time, significantly lower indicators of FSH (by 21.98 %), LH (by 32.89 %) and estradiol (by 32.23 %) were found against their values before sclerotherapy. Performing of sclerotherapy with pregravidary preparation with a complex vitamin medication with inositol and vitamin D3 to women with endometriosis-associated infertility has a positive effect on the hormonal background.