Abstract

Nevi, although benign neoplasms of the skin, but have a certain tendency to malignancy, which is influenced by various external and internal human factors. Predicting the risk of benign nevi against this background is an important topic for experimental research. The aim of the study was to establish the features of the skinfold thickness (SFT) in men of the first adult age with benign nevi. SFT was determined according to the Bunak scheme for men (aged 22-35 years) with melanocyte benign simple nevi (n=34), melanocyte benign dysplastic nevi (n=27), melanocyte benign congenital nevi (n=14) and non-melanocyte benign (n=17). The control group – SFT of 82 practically healthy men of the same age group was selected from the data bank of the Research Center of National Pirogov Memorial Medical University, Vinnytsya. Statistical processing of the results was performed in the license package “Statistica 5.5” using non-parametric evaluation methods. It was found that in practically healthy men higher than in patients – SFT on the anterior and posterior surfaces of the shoulder and thigh (in all groups of patients); SFT on the forearm, at the lower angle of the scapula, chest and shin (only in patients with melanocyte benign dysplastic nevi). Also in healthy men are found lower than in patients – SFT on the side (in all groups of patients); SFT in the abdomen (in patients with melanocyte benign simple and non-melanocyte benign nevi). When comparing SFT between patients with benign nevi, in most cases, lower values of SFT found in patients with melanocyte benign dysplastic nevi. The obtained results indicate the initial manifestations of abdominal (android) type of fat deposition in the body in patients with benign nevi (most pronounced in patients with melanocyte benign simple nevi).

Highlights

  • Nevi are usually benign melanocyte neoplasms that occur either in utero or during life and have different types of localization - both on the skin and on the mucous membranes of the mouth, genitals, etc. [10, 11, 12]

  • According to the latest classifications, melanocytomas, which have a higher risk of malignancy, ie a transitional state between benign and malignant skin neoplasms, are considered a separate type of nevus [7, 21]

  • Men aged 22 to 35 years with benign nevi (34 with melanocyte benign simple nevi, 27 with melanocyte benign dysplastic nevi, 14 with melanocyte benign congenital nevi and 17 with non-melanocyte benign nevi), laboratory tests and histopathological examinations were performed on the base of Military Medical Clinical Center of the Central Region and the Department of Dermatology and Venereal Diseases with a course of postgraduate education National Pirogov Memorial Medical University, Vinnytsya

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Summary

Introduction

Nevi are usually benign melanocyte neoplasms that occur either in utero or during life and have different types of localization - both on the skin and on the mucous membranes of the mouth, genitals, etc. [10, 11, 12]. Nevi are usually benign melanocyte neoplasms that occur either in utero or during life and have different types of localization - both on the skin and on the mucous membranes of the mouth, genitals, etc. According to the latest classifications, melanocytomas, which have a higher risk of malignancy, ie a transitional state between benign and malignant skin neoplasms, are considered a separate type of nevus [7, 21]. When it comes to malignancy of nevi, the worst result of this process is degeneration into melanoma, the prevalence of which is steadily increasing, as is the severity of the consequences it causes. That is why medicine is currently moving towards creating new methods for early diagnosis of skin cancer [20]

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