Features of clinical and biochemical values in patients with various types of non-alcoholic fatty liver disease

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a pandemic of the XXI century. It is estimated that approximately a billion people around the world have NAFLD.Objective: To study some clinical and biochemical values in patients with NAFLD taking into account its type.Material and methods. The study involved 96 patients with NAFLD. 16.67% (16) patients were difgnosed with steatohepatitis and minimum activity of the mesenchymal and inflammatory process, the rest of the patients 83.33% (80) had hepatic steatosis.Results. In case of non-alcoholic steatohepatitis, the mesenchymal-inflammatory syndrome with a decrease in the detoxification and protein-synthetic function of hepatocytes prevails, with some signs of cytolysis, charac-terized by a decrease in the content of the total protein, due to greater growth of alanine aminotransferase (ALT) than aspartate aminotransferase (AST), an increase in the thymol test, in conjugated bilirubin, leukocytes of the peripheral blood and urea. In hepatic steatosis patients mostly have cholestatic (growth of gamma glutamyltranspeptidase (GGT), alkaline phosphatase (ALP) and total cholestorol) predominates, somewhat less mesenchymal-inflammatory and some signs of cytolytic syndromes.Conclusions. The course of NAFLD in patients with essential arterial hy-pertension (EAH) and abdominal obesity (АО) is accompanied by dyslipidemic changes (type II hypercholesterolemia, hypertriglycerolemia) of Type IV (en-dogenous hyperlipidemia by D. Fredrickson) in all patients, which has no unidi-rectional dependence on the levels of obesity and NAFLD type (with prevalence of LDL cholesterol for non-alcoholic steatohepatitis by 16.61%, p<0.05, which, however, does not exceed the reference value).