Features of biodegradation of sol-gel bioactive glass 60S doped with Ga, Ge

Abstract

Samples of BG 60S (4% P2O5, 36% CaO, 60% SiO2) and doped with Ga2О3 (1%), GeО2 (1%) were synthesized by the sol-gel method. In the environment of model physiological fluid (Kokubo's SBF) in vitro biodegradation processes of synthesized BG samples were studied and in vivo studies of bone formation were performed. The methods of atomic absorption (for Ca2+, Mg2+) and photometric (for HPO4 2–) analysis were used to study the change in the ionic composition of the model physiological fluid, the pH changes of which were recorded potentiometrically. BG samples before and after in vitro bioresorption studies were tested by IR spectroscopy. The studied dependences of the activity of ion exchange processes and the rate of formation of hydroxy-carbonate apatite on the surface from doping additives confirm the bioactivity of the synthesized samples. The highest bioactivity according to the results of in vitro and in vivo studies shows BG 60S without alloying additives.