FEATURES OF ATHEROGENESIS AT SENSITIVITY INCREASE TO CANDIDA ALBICANS

Abstract

Objective. To study the content of atherosclerotic plaques in the presence of Candida and analysis of some immunological and biochemical parameters in patients with acute coronary syndrome positive for Candida albicans. Materials and methods. To identify mushrooms in the atherosclerotic plaque-ray was used our method (patent number 531, priority of 28.06.2010). A study was conducted 47 atherosclerotic plaques, taken during the 20 autopsies. It was also examined 80 people with acute coronary syndrome, including 58 men and 22 women, aged 29-85 years, mean age 60,14 ± 10,78 years. All the patients underwent biochemical blood analysis, including TNF-α. Also measured IgG and IgM antibodies to Candida albicans. Results. In 31.9% of cases, the contents of atherosclerotic plaque are fungi of the genus Candida. In most predominant fungi Candida krusii and Candida grabrata, Candida tropicalis isolated colonies and a single colony of Candida albicans. Negative for IgM antibodies to Candida albicans were all 80 (100%) patients, the IgG - 30 (37.5%) patients. In patients negative for IgG, TNF-α was detected in a smaller number of patients (36.7%) than in patients in the positive group (70%), but its level was significantly higher (511,73 ± 195,80 pg / ml , 326,68 ± 259,91 pg / ml, p <0,05). Performance differences between ASAT and ALAT in patients positive for Candida albicans, in the absence of TNF-α was significantly higher than that of other patients. Conclusion. We can assume that Candida species are able to induce inflammation of the vessel wall, which in turn can lead to the development of atherosclerosis.