Features of Adipokines Metabolism in Women with Arterial Hypertension and Obesity, Depending on the Left Ventricular Diastolic Function

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Diastolic dysfunction is often associated with heart failure with a preserved ejection fraction, obesity and often observed in females. The association of adipokines blood levels with diastolic left ventricular dysfunction remains poorly understood.The objective: study of the features of adipokine levels in women with obesity and arterial hypertension depending on the diastolic function.Materials and methods. The study involved 82 patients. Patients with normal diastolic function were assigned to group 1, patients with diastolic dysfunction of the 1st degree – to group 2, and patients with diastolic dysfunction of the 2nd degree – to group 3. Blood levels of adipokines were measured in all patients.Results. The average age of the study group was 51.2±4.4 years. Patients with normal diastolic function had significantly lower plasma leptin levels compared with patients with grade 1 and 2 diastolic dysfunction: 13.3 ng/ml compared to 18.7 ng/ml for grade 1 DD and 24.4 ng/ml at 2 grade of DD (p<0.01). Also, patients with DD 2 grade had a significantly higher level of leptin than patients with grade 1 of DD (p<0.05). Adiponectin levels in patients with normal diastolic function were significantly higher than in patients with grade 2 of DD (p<0.05).Conclusion. In women with arterial hypertension and obesity aged 40–60, there is an association of an increase in blood leptin with an increase in the degree of diastolic disorders of the left ventricular. A significant decrease of adiponectin level in this patients was only in pseudo normal type of left ventricular diastolic dysfunction.