Abstract
The initial design, material and feasibility study for the application of a plastic substrate to an evanescent-wave immunosensor are described. The sensor represents a departure from the fiber-optic and planar waveguide approaches as it is of conical design. It offers possibilities for inexpensive manufacture, processing and ease of incorporation into a disposable unit, since it is injection molded from poly(methyl methacrylate). The low background characteristics and initial performance as an evanescent-wave sensing element are presented. A fluorescence-based competitive assay for digoxin is shown for the range 5–10 ng/ml, which is above the clinical range needed.
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