Feasibility of subcutaneously implanted magnetic microarrays for site specific drug and gene targeting

Abstract

The magnetic nanoparticles play a crucial role as a drug carriers in the human body. The wedge like magnetic arrays creating a strongly non-homogeneous magnetic field are considered as a useful way to focus magnetic nanoparticles functionalized with various drugs or genes to desired sites. The goal of this study is to develop a numerical model of drug targeting using subcutaneously implanted magnetic microarrays. The Finite Element Method is applied to solve partial differential equations describing electromagnetic field (Maxwell equations) and motion of these particles in a given magnetic field is obtained solving set of ordinary differential equations expressed by Newton law of motion. The results are encouraging showing the potential to target drug to the tumour cell locally, without unwanted side effects.