Abstract
In this study, we synthesized azepinooxazepine derivatives in high yields using multicomponent reactions of aniline, diethyl carbonate, alkyl bromides, activated acetylenic compounds, methyl aziridine and Fe3O4/ZnO@MWCNT as a high performance catalyst and teiethyl amine in water at room temperature. The catalytic activity of the green synthesized Fe3O4/ZnO@MWCNT MNCs was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized NCs have very high and effective catalytic activity for organic pollutants within few seconds. Investigation of antioxidant ability of synthesized compounds using radical trapping of DPPH and ferric reduction power experiment is another purpose in this research. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. Also, density functional theory (DFT) based quantum chemical methods have been applied for better understanding reaction mechanism. Highlights Green chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication and applications of chemical products. Among solvents, water is a green solvents and very suitable for performing organic reaction. The present procedure avoids the use of toxic solvent. Some representatives of this class of azaheterocycles are known as antiviral agents, glycosidase inhibitors, anticancer agents or antidiabetics. Therefore, in view of their medicinal relevance, an increasing number of synthetic methods have been described in recent years for the construction of highly substituted azepine derivatives.
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