Abstract
The self-assembly of iron(III) chloride with three pyrazolyl-s-triazine ligands, namely 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)-1,3,5-triazine (PipBPT), 4-(4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine (MorphBPT), and 4,4’-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine (bisMorphPT) afforded [Fe(PipBPT)Cl2][FeCl4] (1), [Fe(MorphBPT)Cl2][FeCl4] (2), and [H(bisMorphPT)][FeCl4]. bisMorphPT.2H2O (3), respectively, in good yield. In complexes 1 and 2, the Fe(III) is pentacoordinated with three Fe-N interactions from the pincer ligand and two coordinated chloride anions in the inner sphere, and FeCl4¯ in the outer sphere. Complex 3 is comprised of one protonated ligand as cationic part, one FeCl4¯ anion, and one neutral bisMorphPT molecule in addition to two crystallized water molecules. Analysis of molecular packing using Hirshfeld calculations indicated that H…H and Cl…H are the most important in the molecular packing. They comprised 40.1% and 37.4%, respectively in 1 and 32.4% and 37.8%, respectively in 2. Complex 1 exhibited the most bioactivity against the tested microbes while 3 had the lowest bioactivity. The bisMorphPT and MorphBPT were inactive towards the tested microbes while PipBPT was active. As a whole, the Fe(III) complexes have enhanced antibacterial and antifungal activities as compared to the free ligands.
Highlights
Iron is a readily available element, as it is considered to be one of the most abundant
Bis-pyrazolyl-s-triazine (BPT) ligands are a class of chelators which have been utilized in the synthesis of several divalent metal ion complexes with interesting molecular and supramolecular structures [8,9,10,11,12,13]
The crystals of the synthesized complexes were obtained from the direct reaction of the
Summary
Iron is a readily available element, as it is considered to be one of the most abundant. Bis-pyrazolyl-s-triazine (BPT) ligands are a class of chelators which have been utilized in the synthesis of several divalent metal ion complexes with interesting molecular and supramolecular structures [8,9,10,11,12,13] These s-triazine pincer-type complexes can be synthesized using self-assembly in a water-alcohol mixture. Several organic-based antibacterial and antifungal drugs were discovered over the last few years [16] Many of these antibiotics cannot overcome the problem of multidrug-resistant. Many of these antibiotics cannot overcome the problem of multidrug-resistant microbes.
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