Abstract
A PRIMARY event of the acute radiation syndrome is depressed haematopoiesis and an associated accumulation of fat cells in the bone marrow cavity. My work has shown that the fatty change occurs only at bone marrow sites directly exposed to ionizing irradiation. On the basis of metabolic investigations, I have concluded that irradiation markedly stimulates the biosynthesis of triglycerides in the bone marrow. Although de novo synthesis of fatty acids by irradiated bone marrow cells is impaired1, both the uptake of lipid and the esterification of fatty acids into triglycerides by marrow cells are markedly stimulated in irradiated animals2. However, the matter of fatty acid oxidation by irradiated marrow cells has not previously been investigated. This communication conclusively demonstrates that fatty acid oxidation is severely inhibited by γ-radiation and that the effect is related to the total dose of radiation received.
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