Abstract
Staphylococcus aureus could produce an enzyme (FAME) which destroyed the activity of bactericidal lipids in abscesses by esterifying the fatty acid moieties to cholesterol. The enzyme was heat labile (60°C/1h) and sensitive to protease K. Optimal activity occurred at pH 6.0 and at 40–50°C, and no cations were required. About 80% of Staphylococcus aureus strains elaborated FAME, but the amount produced by different strains varied considerably. FAME production was the principle mechanism for resistance to the bactericidal lipids, and only FAME-producing staphylococci appeared able to survive within host tissues.
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