Abstract
The unsaturated fatty acids oleic acid and arachidonic acid induced typical apoptosis in Ehrlich ascites tumor cells harvested at the stationary growth phase. Arachidonic acid was a more potent inducer than oleic acid. Apoptosis was induced by concentrations of oleic and arachidonic acids that produced only partial uncoupling of the oxidative phosphorylation. The first symptoms of fatty-acid–induced apoptosis included externalization of phosphatidylserine in the plasma membrane, whereas massive release of cytochrome c from mitochondria to the cytosol followed later on.
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