Abstract
ABSTRACT Studies of serum lipids and of the fatty acid composition of the main fractions were performed in a 17-year-old girl following a large single oral intake of 1-thyroxine. Cholesterol and phospholipids values decreased markedly. These changes were followed by pronounced disturbances in the fatty acid composition of these fractions, with a lowering of linoleic acid, and an increase in arachidonic acid percentages. Other changes were increased oleic acid in the cholesterol esters, and increased eicosatrienoic acid in the phospholipids. The changes were in accordance with findings made in patients with long standing thyrotoxicosis. They support the hypothesis that increased synthesis of arachidonic from linoleic acid contributes to the linoleic acid deficiency seen in thyrotoxicosis. The serum lipids and values for fatty acid composition showed a tendency to return to the original levels within 10 to 15 days. However, in the phospholipids some of the very long-chained fatty acids decreased during the 40-day observation period.
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