Fatty acid composition of platelet total lipid of cholesterol fed rabbit

Abstract

Platelet fatty acid composition (wt%) of human, rat, and rabbit were studied. The results were as follows:(Fatty acids whose wt% higher than 10% were listed.)In rabbit platelet fatty acid composition, the arachidonic acid (20:4) was lowest and the linoleic acid (18:2) was highest among those of the three species. The results of previous study on the platelet fatty acid composition of rabbit fed cholesterol-supplemented diet for six months were also reported. In the study the basic diet (RC-5) and the cholesterol-supplemented diet were obtained from Oriental Kobo Kogyo Co., Tokyo. Ingredients of RC-5 were as follows: Crude fat 4.8g, crude protein 22.8g, and water soluble non-nitrogenous substance 46.2g in 100g. Fatty acid composition of the fat was 16:0, 16.8%, 16:1, 2.3%, 18:0, 2.8%, 18:1, 12.1%, 18:2, 39.3%, and 18:3, 26.7%. The body weight, the serum total cholesterol, and the serum triglycerides of the two groups (the rabbits fed basic diet only and the rabbits fed cholesetrol-supplemented diet) before and six months of experiment were as follows:The platelet fatty acid composition of the two groups at six months experiment were as follows:(Figures indicate mean±SEM.)The platelet fatty acid composition of the cholesterol-supplemented diet group was not significantly different from that of the basic diet group.